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A Y Jeng Selected Research

CGS 26303

8/2001Continuous intravenous infusion of CGS 26303, an endothelin-converting enzyme inhibitor, prevents and reverses cerebral vasospasm after experimental subarachnoid hemorrhage.
11/2000Attenuation of puromycin aminonucleoside-induced glomerular lesions in rats by CGS 26303, a dual neutral endopeptidase/endothelin-converting enzyme inhibitor.
11/2000Design and synthesis of a potent and selective endothelin-converting enzyme inhibitor, CGS 35066.
5/2000Effect of CGS 26303, an endothelin-converting enzyme-neutral endopeptidase inhibitor, on nitrofen-induced congenital diaphragmatic hernia in the rat.

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A Y Jeng Research Topics

Disease

1Hypertension (High Blood Pressure)
06/2006
1Cardiovascular Diseases (Cardiovascular Disease)
06/2006
1Type 2 Diabetes Mellitus (MODY)
06/2006
1Air Embolism (Gas Embolism)
11/2004
1Pulmonary Hypertension
11/2004
1Brain Edema (Cerebral Edema)
02/2002
1Cerebral Infarction
02/2002
1Edema (Dropsy)
02/2002
1Infarction (Infarctions)
02/2002
1Ischemia
02/2002
1Neuralgia (Stump Neuralgia)
02/2002
1Reperfusion Injury
02/2002
1Stroke (Strokes)
02/2002
1Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
08/2001
1Intracranial Vasospasm
08/2001
1Neoplasms (Cancer)
03/2001
1Rheumatoid Arthritis
03/2001
1Osteoarthritis
03/2001
1Animal Disease Models
11/2000
1Septic Shock (Toxic Shock Syndrome)
11/2000
1Liver Diseases (Liver Disease)
11/2000
1Nephrosis
11/2000
1Fibrosis (Cirrhosis)
11/2000
1Congenital Diaphragmatic Hernias
05/2000

Drug/Important Bio-Agent (IBA)

6Endothelins (Endothelin)IBA
06/2006 - 11/2000
4CGS 26303IBA
08/2001 - 05/2000
3Endothelin-Converting EnzymesIBA
08/2001 - 05/2000
2Neprilysin (Neutral Endopeptidase)IBA
06/2006 - 05/2000
2CGS 35601IBA
06/2006 - 06/2006
2Vasopeptidase InhibitorsIBA
06/2006 - 06/2006
2Endothelin A ReceptorIBA
11/2004 - 11/2000
1SaltsIBA
06/2006
1ReninIBA
06/2006
1Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
06/2006
1Antihypertensive Agents (Antihypertensives)IBA
06/2006
1Enzyme Inhibitors (Inhibitors, Enzyme)IBA
11/2004
1CGS 35066IBA
11/2004
1Endothelin B ReceptorIBA
11/2004
1Mexiletine (Mexitil)FDA LinkGeneric
02/2002
1triphenyltetrazoliumIBA
02/2002
1Anti-Arrhythmia AgentsIBA
02/2002
1AntioxidantsIBA
02/2002
1Matrix Metalloproteinases (MMPs)IBA
03/2001
1TransferasesIBA
11/2000
1CollagenIBA
11/2000
1Alanine (L-Alanine)FDA Link
11/2000
1BilirubinIBA
11/2000
1ParaffinIBA
11/2000
1Puromycin AminonucleosideIBA
11/2000
1Messenger RNA (mRNA)IBA
11/2000
1Fixatives (Pickling Agents)IBA
11/2000
1LipopolysaccharidesIBA
11/2000
1nitrofenIBA
05/2000

Therapy/Procedure

1Intravenous Infusions
08/2001
1Ligation
11/2000